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Vivian Ashe leaves her pet chihuahua Chloe with her irresponsible niece Rachel to watch the dog. However, when Rachel decides to go to Mexico with her friends, Chloe gets lost and bonds with Delgado, a lonely German Shepard who used to be a police dog, and goes on the run from a ruthless Doberman called El Diablo. Meanwhile, Papi, a hyperactive chihuahua who falls in love with Chloe, attempts to find his love in Mexico while El Diablo attempts to capture Chloe and get her collar to his owner, a dog fight ringleader.
